Targeting Post-Transplant Myeloid Immune Suppression in Multiple Myeloma: Why CSF-1R Blockade May Enhance Lenalidomide Maintenance After ASCT
Posted inClinical Updates Hematology-Oncology news

Targeting Post-Transplant Myeloid Immune Suppression in Multiple Myeloma: Why CSF-1R Blockade May Enhance Lenalidomide Maintenance After ASCT

A new Blood study links relapse after myeloma ASCT to CSF-1R+ immunosuppressive marrow macrophages and shows that CSF-1R inhibition synergizes with lenalidomide in preclinical models, providing a strong translational rationale for post-transplant combination maintenance.
Subclinical Peripheral Vascular Leakage in Demyelinating Disease-Associated Uveitis: What Ultra-Widefield Angiography Adds Beyond Clinical Quiescence
Posted inClinical Updates news Ophthalmology

Subclinical Peripheral Vascular Leakage in Demyelinating Disease-Associated Uveitis: What Ultra-Widefield Angiography Adds Beyond Clinical Quiescence

A new cohort study suggests ultra-widefield fluorescein angiography frequently detects persistent peripheral leakage in clinically inactive demyelinating disease-associated uveitis, highlighting a potential gap between examination-based remission and angiographic activity.
Portal-Venous Hypothermic Oxygenated Perfusion in Liver Transplantation: Evidence Synthesis from the Bridge to HOPE Trial and Global Clinical Landscape
Posted inClinical Updates General Surgery news Transplantation

Portal-Venous Hypothermic Oxygenated Perfusion in Liver Transplantation: Evidence Synthesis from the Bridge to HOPE Trial and Global Clinical Landscape

This review synthesizes findings from the Bridge to HOPE multicenter trial and other recent evidence, demonstrating that portal-venous hypothermic oxygenated perfusion (HOPE) significantly reduces early allograft dysfunction, improves biliary health, and modulates donor immunogenicity in extended-criteria liver transplantation.
Predictors of Concurrent Endometrial Carcinoma in Minority Populations with Atypical Hyperplasia: A Synthesis of Clinical, Molecular, and Social Evidence
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Predictors of Concurrent Endometrial Carcinoma in Minority Populations with Atypical Hyperplasia: A Synthesis of Clinical, Molecular, and Social Evidence

This review synthesizes recent evidence on concurrent endometrial carcinoma risk in atypical hyperplasia, highlighting significant disparities in minority populations, the protective role of adenomyosis, and the emergence of GLP-1 receptor agonists as metabolic modifiers in fertility-sparing management.