Identification of the adipocyte-derived metabolite 12,13-DiHOME as a primary driver of immune evasion in pancreatic ductal adenocarcinoma (PDAC).
Elucidation of a novel PPARγ-mediated ferritinophagy pathway that sensitizes tumour-associated neutrophils (TANs) to ferroptosis.
Discovery that ferroptotic TANs release CXCL2, which directly suppresses the recruitment and effector function of CD8+ T cells.
Validation of targeting the 12,13-DiHOME/CXCR2 axis as a therapeutic strategy to restore anti-tumour immunity in adipocyte-rich PDAC microenvironments.
