Cardiac Progenitor Cells in Hypoplastic Left Heart Syndrome: Safety Established, but Efficacy Remains Elusive in the CHILD Trial

Highlights

The Phase I CHILD trial confirmed the safety and feasibility of intramyocardial neonatal cardiac progenitor cell (nCPC) injections during the stage 2 palliative operation for Hypoplastic Left Heart Syndrome (HLHS).

The primary efficacy endpoint—improvement in right ventricular (RV) size or function at 1-year follow-up—was not achieved in the randomized cohort.

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