Highlights
1. Annexin A2 (ANXA2) is significantly upregulated in human and murine ischemic hearts, and its circulating levels correlate with the severity of acute myocardial infarction (MI).
2. ANXA2 acts as a molecular brake on mitophagy by competitively binding to the receptor Prohibitin 2 (PHB2), preventing its interaction with LC3B.
