Long-term exposure to PM2.5, PM10, and NO2 is associated with a 20% to 30% increased risk of developing Motor Neuron Disease (MND).
Air pollution not only influences disease onset but also acts as a prognostic factor, with higher exposure linked to faster respiratory and motor functional decline.
The study utilized both population and sibling controls, strengthening the evidence that environmental factors independently contribute to MND beyond genetic predisposition.
Findings suggest that current air quality guidelines may still pose significant risks for neurodegenerative conditions.
Introduction: The Environmental Hypothesis in Neurodegeneration
