Vitamin D Deficiency and Accelerated Bone Loss in Mild to Moderate COPD: New Insights from the Multi-Ethnic Study of Atherosclerosis

Highlights

• Mild to moderate COPD is independently associated with accelerated vertebral bone mineral density (BMD) loss over six years, but only in individuals with vitamin D deficiency.
• Nearly half of the study cohort exhibited vitamin D deficiency, underscoring its prevalence in the general population.
• This finding points to vitamin D status as a potential clinical target to mitigate osteoporosis risk in COPD.

Study Background and Disease Burden