Highlight
- This landmark randomized controlled trial (RCT) is the first to directly compare urgent surgery versus fibrinolytic therapy (FT) using low-dose, slow-infusion tissue plasminogen activator (t-PA) for symptomatic left-sided prosthetic valve thrombosis (PVT).
- The study found no significant difference in complete clinical response between urgent surgery and fibrinolysis but reported significantly higher composite adverse events — particularly death — associated with surgery.
- Fibrinolytic therapy, while safer, was associated with a notable proportion of residual valve dysfunction post-treatment.
Study Background and Disease Burden
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