Highlights
- Sequential bilateral continuous theta burst stimulation (cTBS) targeting temporo-parietal cortex significantly reduces persistent auditory verbal hallucinations (AVH) in schizophrenia spectrum disorders compared to sham stimulation.
- The recent multicentre, triple-blind, sham-controlled phase 3 trial conducted across seven German psychiatric university hospitals demonstrated a clinically meaningful but modest effect size with excellent safety and tolerability.
- The brief 15-session cTBS protocol showed effect sustainability at short-term follow-ups; however, long-term efficacy and maintenance strategies require further elucidation.
- This trial establishes cTBS as an evidence-based neuromodulation option for treatment-refractory AVH, supplementing pharmacotherapy and psychotherapy.
Background
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For clinical reference; use professional judgment.
