Theta Burst Stimulation of the Temporo-Parietal Cortex for Persistent Auditory Hallucinations in Schizophrenia: A Comprehensive Review of a Phase 3 Randomised Multicentre Trial and Contextual Evidence
The recent multicentre, triple-blind, sham-controlled phase 3 trial conducted across seven German psychiatric university hospitals demonstrated a clinically meaningful but modest effect size with excellent safety and tolerability.
The brief 15-session cTBS protocol showed effect sustainability at short-term follow-ups; however, long-term efficacy and maintenance strategies require further elucidation.
This trial establishes cTBS as an evidence-based neuromodulation option for treatment-refractory AVH, supplementing pharmacotherapy and psychotherapy.
