Posted inHematology-Oncology news
Decoding ATRA Resistance in Acute Promyelocytic Leukemia: The Role of PML::RARA Mutations Enhancing Basal Repression
A clustered subset of hotspot PML::RARA mutations drives ATRA resistance in acute promyelocytic leukemia by enhancing basal transcriptional repression rather than disrupting transactivation, suggesting novel mechanisms underlying therapeutic failures.