Posted inHematology-Oncology news
Transcription Factor NFE2: A Crucial Regulator of Redox Balance and Chemotherapy Resistance in Acute Myeloid Leukemia
NFE2 drives leukemic transformation through redox regulation, modulating glutathione homeostasis and detoxification pathways, and confers chemotherapy resistance in AML. Targeting NFE2 may enhance therapeutic efficacy and improve patient outcomes.