Huyết Áp Phổi

Unveiling PUS7’s Role in Pulmonary Hypertension: A Novel Epigenetic Driver of Vascular Remodeling

By MedXY 09/04/2026

This article explores how PUS7-induced pseudouridylation of TGFBI mRNA promotes pulmonary hypertension via epigenetic regulation, revealing promising new therapeutic targets.

Cardiology news Respiratory

Validating the Venous Excess Ultrasound Score (VExUS) for Right Atrial Pressure Assessment in Pulmonary Hypertension: A Multicenter Study

By MedXY 09/03/2026

This multicenter study validates the Venous Excess Ultrasound Score (VExUS) as a highly accurate, noninvasive tool to predict right atrial pressure in patients evaluated for pulmonary hypertension, outperforming isolated echocardiographic markers across diverse hemodynamic profiles.

Cardiology news Respiratory

Pulmonary Artery Stiffness and Right Ventricular Function: A Superior Predictor of Mortality in Mild Pulmonary Hypertension

By MedXY 08/28/2026

This study reveals that pulmonary artery stiffness and right ventricular function parameters independently predict mortality better than pulmonary vascular resistance in mild pulmonary hypertension, supporting their role in early disease risk stratification.

Cardiology news

Unraveling Right Ventricular Failure in PH-HFpEF: Integrative Insights from Vascular Mechanics and Transcriptomics

By MedXY 08/25/2026

This study integrates vascular mechanics, advanced imaging, and myocardial transcriptomics to elucidate the mechanisms of right ventricular failure in pulmonary hypertension secondary to heart failure with preserved ejection fraction, uncovering key vascular and molecular remodeling pathways.

Cardiology news Respiratory

Hypoxia-Induced BACH1 Elevation Drives Pulmonary Hypertension via Activation of TGFBR2/SMAD Signaling

By MedXY 07/15/2026

BACH1 stabilization under hypoxia promotes pulmonary hypertension by enhancing TGFBR2/SMAD pathway activity in pulmonary artery smooth muscle cells, suggesting BACH1 as a promising therapeutic target for PH.

Cardiology news Respiratory

Impact of Short-Term High-Altitude Exposure on Right Ventricular Load and Oxygen Delivery in Pulmonary Vascular Disease Patients

By MedXY 07/05/2026

A two-day stay at 2500 m altitude increases right ventricular afterload and impairs ventricular-arterial coupling but maintains oxygen delivery in stable pulmonary vascular disease patients.

Cardiology news Respiratory

Unveiling the Phenotype of Unclassified Pulmonary Hypertension: A Hidden Spectrum of Early Heart Failure with Preserved Ejection Fraction

By MedXY 06/20/2026

Unclassified pulmonary hypertension often reflects early-stage HFpEF linked to left heart and metabolic dysfunction, identifiable via dynamic right heart catheterization and metabolomics.

news Radiology Respiratory

CT Small-Artery Loss Tracks Severe Pulmonary Hypertension in COPD and Fibrosing ILD More Closely Than Parenchymal Damage

By MedXY 06/02/2026

CT-derived pulmonary vascular metrics, especially the small-artery to total arterial volume ratio, identify severe pulmonary hypertension in chronic lung disease, with distinct vascular remodeling patterns in COPD and fibrosing ILD.

Cardiology news Respiratory

Dual versus monotherapy pretreatment before balloon pulmonary angioplasty in CTEPH: effects on complications and outcomes

By MedXY 05/18/2026

In CTEPH patients undergoing balloon pulmonary angioplasty, dual pulmonary hypertension-targeted pretreatment was linked to fewer thoracic complications and better 6-month clinical improvement than monotherapy.

Cardiology news Oncology

The BMPR2 Nexus: How Breast Cancer Acts as a Second Hit for Pulmonary Hypertension

By MedXY 03/01/2026

Emerging evidence identifies a bidirectional link between breast cancer and pulmonary arterial hypertension (PAH) driven by BMPR2 signaling and IL-1β-mediated inflammation. This study suggests breast cancer may serve as a critical second hit, unmasking latent vascular susceptibility in at-risk populations.