Proteinuria – Medxy AI

Proteinuria in Preeclampsia and Long-Term Risk of Maternal Kidney and Cardiovascular Disease

By MedXY 05/26/2026

Higher proteinuria in preeclampsia was linked to greater long-term risk of maternal hypertension and chronic kidney disease, with overall increased risk of cardiovascular disease as well.

Internal Medicine Nephrology news

Sibeprenlimab Achieves 51% Reduction in Proteinuria for IgA Nephropathy: Key Interim Insights from the Phase 3 VISIONARY Trial

By MedXY 02/22/2026

The Phase 3 VISIONARY trial interim analysis demonstrates that sibeprenlimab, a monoclonal antibody targeting APRIL, significantly reduces proteinuria and pathogenic IgA1 in patients with IgA nephropathy, offering a promising upstream therapeutic approach with a favorable safety profile.

Nephrology news

Selective TRPC6 Inhibition Emerges as a Novel Therapeutic Paradigm for Focal Segmental Glomerulosclerosis

By MedXY 02/16/2026

A Phase 2 trial of BI 764198, a selective TRPC6 inhibitor, demonstrates significant proteinuria reduction in patients with focal segmental glomerulosclerosis. This study provides the first clinical evidence for podocyte-targeted therapy, marking a potential shift in the management of progressive proteinuric kidney diseases.

Allergy & Immunology Nephrology

Oral Iptacopan Shows Promise in Reducing Proteinuria in C3 Glomerulopathy: Results from a Global Phase 3 Trial

By MedXY 10/10/2025

The APPEAR-C3G phase 3 trial demonstrates that oral iptacopan significantly reduces proteinuria and is well tolerated in adults with C3 glomerulopathy, an ultra-rare glomerulonephritis linked to alternative complement pathway overactivation.

Allergy & Immunology Clinical Updates Nephrology Specialties

Emerging APRIL-Targeted Therapies in IgA Nephropathy and IgA Vasculitis Nephritis: Clinical Advances with Zigakibart, Sibeprenlimab, and Telitacicept

By MedXY 08/24/2025

Recent clinical trials of APRIL-targeted monoclonal antibodies—zigakibart, sibeprenlimab, and telitacicept—demonstrate safety and significant proteinuria reduction in IgA nephropathy and IgA vasculitis nephritis, offering promising disease-modifying therapeutic options.

Cardiology news Specialties

Proteinuria Linked to Increased Risk of Sudden Cardiac Arrest in Young Adults

By MedXY 07/27/2025

Recent research uncovers a significant correlation between proteinuria and the risk of sudden cardiac arrest in young individuals, emphasizing the need for early detection and intervention.