pirfenidone – Medxy AI

Comparative Evaluation of Topical versus Systemic Pirfenidone for Prevention of Glottic Stenosis in a Rat Model

By MedXY 09/17/2026

This study investigates the efficacy of topical and systemic pirfenidone in reducing glottic stenosis induced by bleomycin in rats, demonstrating both routes reduce macroscopic stenosis, with systemic administration showing significant antifibrotic effects.

news Respiratory

Deupirfenidone: A New Horizon in Slowing Idiopathic Pulmonary Fibrosis Progression

By MedXY 08/17/2026

Deupirfenidone, a deuterated form of pirfenidone, demonstrated efficacy in slowing lung function decline in IPF patients, with a favorable safety profile in a phase 2b trial, offering promise for improved treatment outcomes.

news Oncology Radiology Respiratory

Pirfenidone plus Steroids Improves Gas Transfer in Grade 2–3 Radiation‑Induced Lung Injury: Phase 2 Multicentre Randomised Trial

By MedXY 11/12/2025

A multicentre phase 2 randomised trial found pirfenidone added to standard glucocorticoids improved DLCO% at 24 weeks versus steroids alone in grade 2–3 radiation‑induced lung injury, with manageable safety and no treatment‑related deaths.