Predictive Value of Midlife and Late-Life Blood Biomarkers for Alzheimer’s Disease and Long-Term Cognitive Decline
This study reveals that midlife plasma p-tau181 predicts faster memory decline over 11 years, highlighting a long prodromal phase of Alzheimer’s disease. Late-life biomarkers p-tau181, NfL, and GFAP correlate with accelerated cognitive decline across domains.
