pertussis – Medxy AI

Clarithromycin vs Azithromycin for Infant Pertussis: Real-World Outcomes from Italian Hospitals

By MedXY 10/03/2026

This multicentre Italian study comparing clarithromycin and azithromycin for hospitalized infants with pertussis shows clarithromycin is linked to better clinical outcomes, including lower severity and fewer ICU admissions.

Infectious Diseases news Pediatrics

Maternal Vaccination and Infant Whole-Cell Pertussis Series Synergize for Superior Mucosal Immunity

By MedXY 01/24/2026

A phase 4 trial in The Gambia reveals that maternal Tdap-IPV vaccination provides early mucosal IgG to infants, while the DTwP primary series induces significantly stronger mucosal antibody and T-cell responses than DTaP, despite maternal antibody interference.

Clinical Updates news Pediatrics Respiratory Specialties

Impact of Maternal Pertussis Vaccination on Infant Immune Responses: Insights from the GaPS Trial in The Gambia

By MedXY 08/02/2025

A phase 4 trial in The Gambia finds that maternal Tdap-IPV vaccination is safe and provides early infant protection, but modestly blunts immune responses to whole-cell pertussis vaccines without compromising overall immunogenicity.