慢性神経障害性疼痛に対する脊髄刺激療法と理学療法士主導運動・運動処方併用の長期効果：臨床レビュー
Posted inClinical Updates Neurology news

Long-term Effects of Spinal Cord Stimulation Combined with Physiotherapist-led Exercise and Prescribed Physical Activity in Chronic Neuropathic Pain: A Clinical Review

This review synthesizes evidence on spinal cord stimulation combined with physiotherapist-led exercise and physical activity prescriptions, highlighting sustained pain relief and quality-of-life improvements without significant increases in physical activity over 21 months.
Pregabalin Restores Sleep and Circadian Rhythms in Neuropathic Pain—Unlike Morphine: Translational Insights from a Mouse SNI Model
Posted inAnesthesiology Neurology news

Pregabalin Restores Sleep and Circadian Rhythms in Neuropathic Pain—Unlike Morphine: Translational Insights from a Mouse SNI Model

In a mouse spared nerve injury model, pregabalin—but not morphine—restored REM sleep, normalized locomotor and temperature circadian rhythms, and reversed spinal circadian gene changes. Findings suggest analgesic choice can differentially affect sleep and circadian biology in neuropathic pain.