Highlights
- Establishment of a fully humanized iPSC-based co-culture model to study interactions between macrophages and sensory neurons.
- Discovery that iPSC-derived macrophages (iMacs) undergo specific morphological and secretory changes in direct response to the injury state of sensory neurons.
- Evidence that macrophages directly amplify spontaneous firing in damaged sensory neurons, providing a mechanistic link between innate immunity and neuropathic pain.
- Identification of neuro-immune signaling pathways as high-priority targets for the development of next-generation non-opioid analgesics.
Background: The Clinical Burden of Neuropathic Pain
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