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lipid homeostasis

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Liver-Derived Apolipoprotein J Drives Diabetic Kidney Injury by Disrupting TFEB-Mediated Lipid Regulation
Posted inDiabetes & Endocrinology Nephrology news

Liver-Derived Apolipoprotein J Drives Diabetic Kidney Injury by Disrupting TFEB-Mediated Lipid Regulation

Posted by By MedXY 10/05/2026
This study reveals that liver-secreted apolipoprotein J accumulates in renal tubules, disrupting TFEB-mediated lipid homeostasis and exacerbating diabetic kidney disease, highlighting a novel therapeutic target with the ApoJ antagonist MK53.
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