hearing loss – Medxy AI

Uncovering Novel Genetic Contributors to Usher Syndrome: Insights from Comprehensive Mouse Knockout Models

By MedXY 10/26/2026

A large-scale phenotypic screen of 9,139 knockout mouse lines identified 18 candidate genes linked to retinal and hearing abnormalities, offering promising new targets for understanding and diagnosing Usher syndrome.

Neurology news Otorhinolaryngology

Evaluating Hearing Aid Intervention in Older Adults with Mild Cognitive Impairment: Insights from the CHOICE Randomized Clinical Trial

By MedXY 10/04/2026

The CHOICE trial investigated whether hearing aid intervention reduces dementia progression in older adults with mild cognitive impairment and hearing loss, finding no significant reduction in dementia incidence but increased cognitive improvement rates.

Clinical Updates news Otorhinolaryngology

Hearing Loss and Regional Brain Amyloid Deposition: Insights from In Vivo PET Imaging and Neuropathological Correlates

By MedXY 10/01/2026

This review synthesizes evidence linking hearing loss to regional brain amyloid deposition, highlighting recent in vivo PET findings, meta-analytic data on AD neuropathology, and amyloid-related inner ear pathology, discussing potential mechanisms and future research directions.

news Otorhinolaryngology

Beyond Binary: A 4-Stage Risk Stratification Tool Transforms Cochlear Implant Candidacy Assessment

By MedXY 04/02/2026

Researchers developed a novel 4-level classification system using routine audiometric data to estimate cochlear implant candidacy likelihood, moving beyond traditional binary screening approaches to support personalized shared decision-making in clinical practice.

news Otorhinolaryngology

Hearing Loss Delays Semantic Prediction When Listening Is Demanding: Two-Stage Prediction Impaired by Cognitive Load

By MedXY 11/04/2025

A visual-world eye-tracking study in older adults shows that postlingual hearing loss delays verb-driven semantic prediction—especially under higher listening demand—while simple agent-based prediction is preserved.

Diabetes & Endocrinology news Otorhinolaryngology

Type 2 Diabetes Quadruples Risk of Hearing Loss — Meta-analysis Finds Predominant High-Frequency Impairment and Links to Duration and HbA1c

By MedXY 11/04/2025

A PRISMA systematic review and meta-analysis of 17 studies (2019–2024) found type 2 diabetes is associated with a 4.19-fold greater odds of hearing loss, especially at high frequencies; duration >10 years and higher HbA1c amplified risk.

news Otorhinolaryngology Pediatrics

DB-OTO Gene Therapy: A Breakthrough Treatment for OTOF-Related Inherited Deafness in Children

By MedXY 10/24/2025

Regeneron's DB-OTO gene therapy shows promising results in restoring natural hearing in children with profound hearing loss caused by OTOF gene mutations, with 75% achieving significant hearing improvement after a single treatment.