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Insights from Neuron-Derived Extracellular Vesicle Biomarkers: PPARγ and GLP1 Receptor Agonists Modulate Brain Metabolism in CNS Insulin Resistance
This review synthesizes clinical trial evidence showing that PPARγ and GLP1 receptor agonists modulate brain insulin signaling biomarkers in neuropsychiatric and neurodegenerative disorders, revealing CNS-specific metabolic effects beyond peripheral insulin resistance improvements.