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genetic screening

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Impact of Population-Based Pathogenic Variant Testing on Risk-Based Breast Screening Recommendations: A Secondary Analysis of the WISDOM Study
Posted innews Oncology Public Health

Impact of Population-Based Pathogenic Variant Testing on Risk-Based Breast Screening Recommendations: A Secondary Analysis of the WISDOM Study

Posted by MedXY By MedXY 06/09/2026
This WISDOM Study analysis found that most women with breast cancer pathogenic variants would not have been flagged for high-risk screening by clinical or polygenic risk models alone, supporting population-based genetic testing.
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MBD4 Germline Variants Mark a Strong Predisposition to Uveal Melanoma, Supporting Broad Genetic Screening
Posted innews Oncology Ophthalmology

MBD4 Germline Variants Mark a Strong Predisposition to Uveal Melanoma, Supporting Broad Genetic Screening

Posted by MedXY By MedXY 05/04/2026
A large French case series found pathogenic or likely pathogenic germline MBD4 variants in 23 of 896 patients with uveal melanoma, corresponding to a 31-fold relative risk versus the general population.
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  • When Sleep Studies Disagree: How Night-to-Night Variability and AHI Scoring Rules Change OSA Diagnosis
  • Why One Sleep Study Is Not Always Enough: Night-to-Night Variability and AHI Reclassification in Obstructive Sleep Apnea
  • Why One Sleep Study May Not Tell the Whole Story: Night-to-Night Variability, AHI Definitions, and OSA Reclassification
  • Early Neutrophil and Persistent Eosinophil Gene Signatures in Childhood Asthma
  • Ripasudil After DSO in Fuchs Endothelial Corneal Dystrophy: A Randomized Trial Signals a New Path to Corneal Recovery
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