二甲双胍联合孕激素用于子宫内膜肿瘤保留生育治疗:FELICIA 试验带来的启示

Adjunctive Metformin with Progestin in Fertility-Sparing Treatment of Endometrial Neoplasia: Insights from the FELICIA Trial

The FELICIA phase IIb trial found that adding metformin to progestin therapy for fertility-sparing treatment in endometrial neoplasia did not improve 3-year recurrence-free survival or remission rates, though some reproductive outcomes favored metformin. Safety was consistent with known profiles.