blood–brain barrier

Clinical Implications of Hyperintense Reperfusion Marker and Ocular Gadolinium Leakage Post-Thrombectomy: Insights from the ETIS Registry

By MedXY 08/25/2026

This review elucidates the prognostic significance of HARM and GLOS as imaging biomarkers after mechanical thrombectomy, highlighting their associations with early neurological outcomes and infarct progression.

Cardiology Neurology news

DKK2 Inhibition: A Novel Neurovascular Strategy to Salvage the Ischaemic Penumbra and Protect the Blood-Brain Barrier

By MedXY 01/02/2026

New research published in the European Heart Journal identifies Dickkopf-related protein 2 (DKK2) as a primary driver of neurovascular injury post-stroke. By suppressing Wnt signalling, DKK2 exacerbates neuronal death and blood-brain barrier breakdown, marking it as a high-priority therapeutic target.

Neurology news Pediatrics

Breakthrough in Hunter Syndrome: Brain-Penetrant Enzyme Therapy Stabilizes Cognitive Function and Clears Lysosomal Substrates

By MedXY 12/31/2025

A Phase 1-2 study of tividenofusp alfa reveals a 91% reduction in CSF heparan sulfate and stabilized adaptive behavior in children with MPS II, overcoming the blood-brain barrier via transferrin receptor-mediated transport.

Neurology news Oncology

Microbubble‑Enhanced Focused Ultrasound with Temozolomide Shows Feasibility and Promising Survival in High‑Grade Glioma — Phase 1/2 Multicentre Results

By MedXY 11/29/2025

A multicentre phase 1/2 trial reports that MRI‑guided microbubble‑enhanced transcranial focused ultrasound (MB‑FUS) can safely open the blood–brain barrier and be combined with standard adjuvant temozolomide in high‑grade glioma, with median overall survival 31.3 months and feasibility for non‑invasive plasma biomarker monitoring.

Clinical Updates Neurology Specialties

Early-Life Gut Microbiome Maturity: A Key Regulator of Blood-Brain Barrier Integrity and Cognitive Development

By MedXY 09/29/2025

This study demonstrates that the maturity of the early-life gut microbiome influences blood-brain barrier integrity and cognitive functions, highlighting a novel therapeutic target for neurodevelopmental disorders.

Neurology news Specialties

Harnessing Exosomes in Neurodegenerative Diseases: Therapeutic Promise and Modification Techniques

By MedXY 08/20/2025

Exosomes, nanoscale vesicles capable of crossing the blood–brain barrier, hold significant potential as targeted therapeutic agents and diagnostic markers in neurodegenerative diseases. Advances in genetic, chemical, and nanomaterial modifications enhance their targeting, representing a promising frontier for treatment.