adverse events – Medxy AI

Higher Oral Corticosteroid Exposure in Chronic Rhinosinusitis With Nasal Polyps Is Linked to More Systemic Harm

By MedXY 06/06/2026

A nationwide Korean nested case-control study found that longer annual duration and higher cumulative oral corticosteroid dose in chronic rhinosinusitis with nasal polyps were associated with increased systemic adverse events, supporting steroid-sparing management.

news Oncology Otorhinolaryngology

Pembrolizumab Dominates the HNC Market While Immune-Related Adverse Events Persist in Real-World Practice

By MedXY 02/19/2026

A large-scale cohort study of 47,365 head and neck cancer patients reveals a significant market shift toward pembrolizumab and a 41.2% incidence of immune-related adverse events, though severe toxicities remain rare and are linked to specific baseline comorbidities.

Internal Medicine Psychiatry Specialties

Comparative Effectiveness of Long-Acting Injectable Versus Oral Antipsychotics in Older Adults with Schizophrenia: Insights from Hong Kong’s Population-Based Study

By MedXY 10/18/2025

This study compares long-acting injectable to oral antipsychotics in older schizophrenia patients, highlighting benefits in relapse prevention and mortality reduction, with specific considerations for adverse effects.

Hematology-Oncology news

Enhancing Patient Experience in DLBCL: Insights from PROs and Clinician-Reported AEs in the Phase 3 POLARIX Trial

By MedXY 10/14/2025

The POLARIX trial demonstrates superior progression-free survival with Pola-R-CHP in untreated DLBCL, highlighting the utility of patient-reported outcomes alongside clinician-reported adverse events to capture symptom burden and quality of life comprehensively.

Cardiology Clinical Updates news Specialties

Balancing Benefits and Harms of Intensive Blood Pressure Control Across Cardiovascular Risk Levels

By MedXY 08/12/2025

Intensive blood pressure control reduces cardiovascular events across all risk levels, with greater absolute benefits in higher-risk patients despite increased adverse events, supporting tailored treatment based on cardiovascular risk.

Clinical Updates news Specialties Urology

Testosterone Therapy in Middle-Aged and Older Men with Hypogonadism: Balancing Clinical Benefits and Risks

By MedXY 08/07/2025

Testosterone therapy offers modest benefits for sexual function, anemia, and bone health in older men with hypogonadism, but increases risks of venous thromboembolism, fractures, and arrhythmias. Careful patient selection and individualized risk-benefit assessment are essential.

Clinical Updates news OB/GYN & Women's Health Specialties

Mini Copper IUDs: Efficacy, Safety, and Continuation Compared to Standard Devices

By MedXY 08/05/2025

A large randomized trial demonstrates that the NTCu380 Mini copper IUD offers comparable contraceptive efficacy to the standard TCu380A, with fewer side effects leading to discontinuation, especially in nulliparous women.