Sustained Symptom Control over Five Years: Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson Disease

Highlight

– Subthalamic nucleus deep brain stimulation (STN-DBS) produces durable motor improvement in Parkinson disease (PD) over five years.
– STN-DBS significantly suppresses dyskinesia and improves activities of daily living without medication.
– A stable 28% reduction in levodopa-equivalent dose is maintained throughout five years.
– Treatment shows a favorable safety profile, with infections as the most common serious adverse event.

Study Background and Disease Burden