Highlight
- Statin therapy in MASLD patients significantly lowers serum liver enzymes and LDL cholesterol, especially in older adults.
- Transcriptomic analyses reveal statin-associated suppression of cellular senescence pathways and activation of ferroptosis-linked pathways in the liver.
- Age and sex influence liver transcriptomic responses to statins, suggesting differential regulation of liver aging during systemic metabolic dysfunction.
- Statins may act as senolytic agents, offering protection against biological liver aging and highlighting complex roles of senescence in liver remodeling.
Study Background
Specialty calculators
For clinical reference; use professional judgment.
