Internal Medicine – Page 12

Tirzepatide Shows Unprecedented Weight Loss and Reduced Insulin Demand in Adults with Type 1 Diabetes and Obesity

By MedXY 12/30/2025

A Phase 2 trial demonstrates that tirzepatide significantly reduces body weight, HbA1c, and total daily insulin requirements in adults with type 1 diabetes and obesity, offering a promising therapeutic strategy for managing metabolic health in this population.

Internal Medicine news Oncology

Lay Health Worker-Led Symptom Monitoring Slashes Acute Care Use and Costs in Older Cancer Patients

By MedXY 12/30/2025

A multisite RCT published in JAMA reveals that lay health worker-led symptom assessments for older adults with cancer significantly reduce emergency department visits, hospitalizations, and healthcare costs, offering a scalable model for geriatric oncology care.

Internal Medicine news Psychiatry

Low-Dose Amitriptyline vs. CBT-I for Comorbid Insomnia: Statistical Non-Inferiority Meets Clinical Reality

By MedXY 12/30/2025

A multicenter trial finds low-dose amitriptyline non-inferior to CBT-I for comorbid insomnia based on a liberal margin. However, CBT-I yielded superior clinical response rates and fewer side effects, reinforcing its status as the gold-standard treatment.

Emergency Medicine Internal Medicine Neurology news

One in Three Older Emergency Admissions Face Cognitive Morbidity: Insights from the ORCHARD-EPR Study

By MedXY 12/29/2025

A large-scale cross-sectional study of 51,202 admissions reveals that 35.6% of patients aged 70 and older experience cognitive morbidity, predominantly delirium. The findings underscore the urgent necessity for hospital-wide screening and multidisciplinary geriatric support across nearly all medical and surgical specialties.

Infectious Diseases Internal Medicine news

Subcutaneous Lidocaine-HP-β-CD: A Potential Disease-Modifying Breakthrough for Post-COVID Condition

By MedXY 12/29/2025

A 36-week observational study demonstrates that subcutaneous lidocaine-HP-β-CD significantly improves physical and mental quality of life and reduces symptom burden in patients with post-COVID condition, offering a scalable, home-based therapeutic option for a currently underserved patient population.

Cardiology Internal Medicine news

Beyond Congestion: The Wet-Cold Phenotype Drives Mortality in Obese HFpEF

By MedXY 12/29/2025

A hemodynamic study of 227 HFpEF patients reveals that 34% exhibit a low-output phenotype. This cold status, especially when combined with congestion, significantly increases mortality risk in overweight and obese individuals, highlighting the need for precise hemodynamic profiling.

Critical Care Internal Medicine news

Melatonin Does Not Prevent Delirium in the Intensive Care Unit: Insights from a Comprehensive Meta-Analysis

By MedXY 12/28/2025

A recent systematic review and meta-analysis of 13 randomized controlled trials concludes that melatonin fails to reduce the incidence of delirium or mortality in critically ill patients, challenging the routine use of this supplement in the intensive care setting.

Critical Care Internal Medicine news

Melatonin in the ICU Does Not Translate to Reduced Delirium Incidence

By MedXY 12/28/2025

The DEMEL trial found that while 0.3 mg of melatonin achieved a superior pharmacokinetic profile over 3 mg, it failed to reduce delirium incidence or improve clinical outcomes in mechanically ventilated patients compared to placebo.

Critical Care Internal Medicine news

Higher Blood Pressure Targets in Septic Shock: When More Vasopressors Do More Harm than Good

By MedXY 12/27/2025

A post-hoc analysis of the SEPSIS-PAM trial reveals that while high MAP targets do not provide a universal survival benefit, they significantly increase mortality risk when requiring high norepinephrine doses or failing to resolve microcirculatory dysfunction like skin mottling.

Cardiology Internal Medicine news

Redefining Iron Deficiency in Heart Failure: Why TSAT and Serum Iron Outperform Ferritin for Prognosis

By MedXY 12/26/2025

Recent large-scale studies, including HEART-FID and major national registries, demonstrate that transferrin saturation (TSAT) and serum iron levels are more accurate predictors of functional capacity and mortality in heart failure than traditional ferritin-based definitions.

Cardiology Internal Medicine news

Beyond the Scale: Abdominal Adiposity Outperforms BMI in Predicting Outcomes for HFpEF and HFmrEF

By MedXY 12/26/2025

A pooled analysis of 21,479 HFpEF/HFmrEF patients reveals that waist-to-height ratio is a superior, linear predictor of mortality and heart failure events compared to BMI. Even in non-obese BMI categories, nearly 90% of patients exhibit excess abdominal adiposity, necessitating a shift in clinical assessment.

Cardiology Internal Medicine news

Rethinking Biomarker Thresholds: Why Current NT-proBNP Cutoffs Fail Patients with Obesity and HFpEF

By MedXY 12/26/2025

A pooled analysis of 14,750 patients reveals that current fixed NT-proBNP thresholds significantly underestimate cardiovascular risk in obese patients with heart failure, suggesting a critical need for BMI-adjusted diagnostic and trial eligibility cutoffs.

Cardiology Internal Medicine news

High BMI, High Benefit: How PCSK9 Inhibition Optimizes Outcomes in Obese Patients with ASCVD

By MedXY 12/25/2025

A prespecified analysis of the FOURIER trial reveals that patients with obesity and atherosclerotic cardiovascular disease experience significantly higher absolute and relative risk reductions with evolocumab, particularly those with a BMI above 35 kg/m2, emphasizing a targeted therapeutic advantage for this high-risk population.

Internal Medicine Neurology news

Blarcamesine in Early Alzheimer’s Disease: Promising Results Amidst Controversies

By MedXY 12/25/2025

Blarcamesine shows potential in slowing early Alzheimer's progression, but questions about trial data robustness and transparency have been raised.

Cardiology Internal Medicine news

N-Palmitoyl Glutamine: A Novel Molecular Link Between Exercise, Mitochondrial Efficiency, and Human Longevity

By MedXY 12/25/2025

A groundbreaking study identifies N-palmitoyl glutamine (NPG) as a key molecular transducer of cardiorespiratory fitness. NPG correlates with VO2max, increases with exercise training, predicts lower mortality, and directly enhances mitochondrial function, offering a potential therapeutic target for cardiometabolic health.

Cardiology Internal Medicine news

Alirocumab Neutralizes the Pro-inflammatory Risk of Oxidized Phospholipids After Acute Coronary Syndrome

By MedXY 12/25/2025

A secondary analysis of the ODYSSEY OUTCOMES trial reveals that oxidized phospholipids on apolipoprotein B-100 (OxPL-apoB) independently predict cardiovascular risk in ACS patients, particularly when Lp(a) levels are low. Treatment with alirocumab effectively mitigates this risk while significantly reducing biomarker levels.

Cardiology Internal Medicine news

Beyond Traditional Risk Scores: How Preclinical Measures Refine Heart Failure Prediction in the ARIC Study

By MedXY 12/24/2025

Recent findings from the ARIC study reveal that integrating cardiac biomarkers and echocardiography with the PREVENT-HF score significantly enhances the prediction of incident heart failure, identifying high-risk individuals who traditional clinical models might otherwise overlook.

Clinical Updates Internal Medicine news Psychiatry

Tailored Weight Loss Interventions in Serious Mental Illness: A Comprehensive Review of Evidence and Clinical Implications

By MedXY 12/24/2025

This review synthesizes evidence on tailored weight loss programs for adults with serious mental illness, highlighting recent advances, effectiveness, mechanistic insights, and future directions.

Clinical Updates Internal Medicine news Psychiatry

Tailored Weight Loss Interventions for Veterans with Serious Mental Illness: Efficacy and Implementation Insights from Recent RCT Evidence

By MedXY 12/24/2025

This review synthesizes evidence from a 2025 randomized clinical trial evaluating a tailored weight loss program, CoachToFit, for veterans with serious mental illness, highlighting its potential to improve weight outcomes via remote support technologies and peer-led interventions.

Clinical Updates Dermatology Gastroenterology Internal Medicine news

Causal Insights Into Hidradenitis Suppurativa: Mendelian Randomization Evidence Linking BMI, Inflammatory Bowel Disease, and Smoking

By MedXY 12/24/2025

Recent Mendelian randomization analyses demonstrate causal effects of increased BMI and inflammatory bowel disease on hidradenitis suppurativa risk, elucidating modifiable contributions beyond genetic correlations with psoriasis and systemic sclerosis.