Each Hour Sitting Counts: Sedentary Time Linked to Lower Intrinsic Capacity and Faster Decline in Older Adults
Posted inInternal Medicine news Public Health Rehabilitation Medicine

Each Hour Sitting Counts: Sedentary Time Linked to Lower Intrinsic Capacity and Faster Decline in Older Adults

In a prospective Beijing cohort (BLINDSCE), each additional hour of daily sedentary time was associated with a 1.18-point lower baseline intrinsic capacity and a 0.48-point greater decline over 1 year, suggesting sedentary behavior is a modifiable target to preserve healthy aging.
How Much Aerobic Exercise Is Enough to Reduce Depression in Patients with Chronic Illness? A Dose–Response Meta-analysis Points to an Achievable Target
Posted inInternal Medicine news Psychiatry Rehabilitation Medicine

How Much Aerobic Exercise Is Enough to Reduce Depression in Patients with Chronic Illness? A Dose–Response Meta-analysis Points to an Achievable Target

A meta-analysis of 36 RCTs (n=2,500) found aerobic exercise significantly reduces depressive symptoms in people with chronic illness (Hedges' g -0.73). A weekly dose of ≈405 MET‑min (≈120–135 min of moderate aerobic activity) reaches a minimally important symptom change.
Red Blood Cell Metabolism Modulates Muscle Oxygenation and Limits Exercise Capacity: Insights from a Randomized Double‑Blind Crossover Study
Posted inInternal Medicine news

Red Blood Cell Metabolism Modulates Muscle Oxygenation and Limits Exercise Capacity: Insights from a Randomized Double‑Blind Crossover Study

A randomized crossover study in 20 men shows exercise‑induced oxidative stress alters erythrocyte redox and glycolytic metabolism, reduces 2,3‑BPG/ATP generation, and modestly impairs muscle oxygen extraction and arm exercise VO2peak, suggesting erythrocyte metabolism can influence exercise performance.
Urolithin A in Elite Distance Runners: Improves Recovery and Perceived Effort but Not Race Performance in 4-Week Altitude Training
Posted inInternal Medicine news Public Health

Urolithin A in Elite Distance Runners: Improves Recovery and Perceived Effort but Not Race Performance in 4-Week Altitude Training

A randomized, placebo-controlled trial in highly trained male distance runners found 4 weeks of 1000 mg/day urolithin A reduced markers of muscle damage and perceived exertion and upregulated mitochondrial proteomic pathways, but did not produce statistically significant performance gains in a 3000 m time trial.
Comparative Efficacy and Safety of Tirzepatide, Semaglutide, and Liraglutide for Obesity Management: A Critical Review of Recent Cochrane Evidence
Posted inDiabetes & Endocrinology Internal Medicine news

Comparative Efficacy and Safety of Tirzepatide, Semaglutide, and Liraglutide for Obesity Management: A Critical Review of Recent Cochrane Evidence

This article critically compares the efficacy, safety, and long-term outcomes of tirzepatide, semaglutide, and liraglutide for the treatment of obesity based on recent Cochrane systematic reviews, highlighting differences in weight loss, adverse events, cardiovascular outcomes, and evidence certainty.