Plant-Based Foods and Their Impact on Metabolic Health and Liver Function in Adults with MASLD and Comorbidities: A Systematic Review
Posted inDiabetes & Endocrinology Gastroenterology news

Plant-Based Foods and Their Impact on Metabolic Health and Liver Function in Adults with MASLD and Comorbidities: A Systematic Review

This systematic review evaluates the effects of specific plant-based foods on metabolic and hepatic outcomes in adults with MASLD and related comorbidities. Findings reveal selective benefits of plant-based dietary components on liver health, glycemic control, and lipid profiles, underscoring potential dietary strategies for MASLD management.
Evaluating Surrogate Endpoints in Advanced Biliary Tract Cancer: Progression-Free Survival Outperforms Response Rates as a Predictor of Overall Survival
Posted inGastroenterology news Oncology

Evaluating Surrogate Endpoints in Advanced Biliary Tract Cancer: Progression-Free Survival Outperforms Response Rates as a Predictor of Overall Survival

This comprehensive analysis reveals that progression-free survival moderately correlates with overall survival in advanced biliary tract cancer, while objective response and disease control rates show poor correlation, underscoring the need for better surrogate markers in clinical trials.
Unraveling Non-Acute Decompensation in Cirrhosis: A Distinct Clinical and Pathophysiological Entity with Prognostic Implications
Posted inGastroenterology Internal Medicine news

Unraveling Non-Acute Decompensation in Cirrhosis: A Distinct Clinical and Pathophysiological Entity with Prognostic Implications

Non-acute decompensation of cirrhosis (NAD) represents a distinct clinical state characterized by elevated cell death markers and moderate prognosis. Identifying predictors such as ascites severity and biomarkers Gasdermin-D and RIPK3 may guide timely interventions to prevent progression to acute decompensation and reduce mortality.
Elevated Risk of Alcohol-Related Liver Disease and Mortality in Patients Undergoing Treatment for Alcohol Use Disorder: Insights from a Nationwide Danish Cohort
Posted inGastroenterology

Elevated Risk of Alcohol-Related Liver Disease and Mortality in Patients Undergoing Treatment for Alcohol Use Disorder: Insights from a Nationwide Danish Cohort

This study quantifies the heightened risk of alcohol-related liver disease, cancer, cardiovascular mortality, and all-cause death among individuals receiving treatment for alcohol use disorder compared to the general population, emphasizing the need for targeted screening and integrated care.
Innovative Extracorporeal Therapy Combining HLA-Depleted Liver Organoids and Granulocyte-Monocyte Apheresis for Reversal of Acute Liver Failure
Posted inCritical Care Gastroenterology news

Innovative Extracorporeal Therapy Combining HLA-Depleted Liver Organoids and Granulocyte-Monocyte Apheresis for Reversal of Acute Liver Failure

The UTOpiA system, integrating HLA-depleted iPSC-derived liver organoids with granulocyte-monocyte apheresis, significantly improves survival and liver regeneration in acute-on-chronic and acute liver failure rat models, representing a promising off-the-shelf extracorporeal liver support therapy.