Healthy Nordic Diet vs. Anti-Lipogenic High-Fat Diet: Superior Cardiometabolic Outcomes in the NAFLDiet Trial

Highlights

  • Both a low-carbohydrate high-polyunsaturated fat (LCPUFA) diet and a Healthy Nordic Diet (HND) significantly reduced liver fat compared to usual care over 12 months.
  • The Healthy Nordic Diet led to greater reductions in body weight and HbA1c compared to both the LCPUFA diet and usual care.
  • Only the HND group showed significant improvements in systemic inflammation (CRP), triglycerides, and liver enzymes (ALT/AST).
  • Both active diets similarly reduced LDL-cholesterol, demonstrating the lipid-lowering potential of replacing saturated fats with plant-based sources or whole grains.

Background and Clinical Context

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