Postoperative recurrence of Crohn’s disease involves distinct shifts in the mucosa-associated microbiota, notably decreases in Faecalibacterium prausnitzii and increases in Akkermansia muciniphila.
The Rutgeerts score, measuring endoscopic recurrence severity, relates to specific microbial signatures, emphasizing the value of multilevel microbiota analysis rather than binary classification.
Network analysis reveals a denser microbial community after surgery in patients without recurrence, indicating dynamic ecosystem reorganization related to disease status.
The study integrates microbial compositional changes with clinical outcomes, advancing our understanding of post-ileal resection Crohn’s disease pathophysiology.
