Redefining Post-Cardiac Arrest Care: Two-Year TTM2 Data Confirm No Long-Term Advantage for Targeted Hypothermia

Highlights

  • Targeted hypothermia at 33°C does not improve functional outcomes or societal participation at 24 months compared to targeted normothermia with early fever management.
  • Cognitive outcomes, measured by MoCA and SDMT, showed no significant difference between the two temperature strategies in the long term.
  • The majority of functional recovery occurs within the first six months post-arrest, followed by a general plateau in the overall population.
  • Despite the population-level plateau, significant intraindividual variability exists, with some patients continuing to improve or decline up to two years later.

The Evolution of Temperature Management in Post-Cardiac Arrest Care

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