Highlights
– In a randomized trial of older, higher‑risk patients undergoing major abdominal surgery, a prophylactic, titrated norepinephrine infusion started at induction markedly reduced episodes of intraoperative hypotension compared with reactive ephedrine boluses.
– The intervention group experienced fewer 30‑day medico‑surgical complications (Clavien‑Dindo ≥1) and fewer pulmonary complications; other secondary outcomes (AKI, length of stay, 1‑month mortality) were not statistically different.
