Personalizing Oxaliplatin Dosing: Reducing Neurotoxicity in Stage III Colon Cancer—Insights from the LEANOX Trial

Highlights

  • LBM-based oxaliplatin dosing reduced grade ≥2 peripheral neurotoxicity compared to standard dosing.
  • No compromise in relapse-free or overall survival when using LBM-adjusted doses.
  • Quality of life was improved, and fewer dose reductions were needed in the LBM-based group.

Study Background and Disease Burden

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