Switching from injectable to oral antibiotics after 48 hours is safe and effective for young infants with moderate-risk possible serious bacterial infection (PSBI).
Early hospital discharge reduces inpatient stay duration without increasing poor clinical outcomes, including mortality and severe infection signs.
High treatment adherence to oral amoxicillin was achieved across diverse low- and middle-income countries, supporting feasibility.
This strategy may optimize health system capacity and reduce risks of hospital-acquired infections in resource-limited settings.
