Neural Connectivity Patterns Predict Acupuncture Response in Migraine: A Step Toward Personalized Pain Management

Real acupuncture significantly reduced monthly migraine days (MMDs) compared to sham acupuncture (median difference, -1.0; P = .02).
Significant improvements were observed in secondary outcomes, including pain intensity (VAS), headache impact (HIT-6), and quality of life (MSQ).
Connectome-based predictive modeling (CPM) identified distinct baseline neural signatures that predict clinical response.
DMN-SC hypoconnectivity was a key predictor for pain relief, while SC-motor hyperconnectivity predicted reduced disability.