Can Modafinil Break the Sleep–Mood Cycle in People Living with HIV?

Highlights

– Sleep disorders, including insomnia and obstructive sleep apnea (OSA), are highly prevalent in people living with HIV (PLWH), with subclinical OSA reported in up to 70% in polysomnography-based studies.

– Daytime excessive sleepiness (EDS) and cognitive dysfunction are common and impair safety, function, and quality of life; standard OSA therapy (CPAP) has adherence limits and residual symptoms in many patients.

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