Highlights
– Large multi-cohort human study links gut microbial tryptophan metabolism to attention deficits in obesity, identifying 3‑hydroxyanthranilic acid (3‑HAA) as positively associated with attention and anthranilic acid (AA) as negatively associated.
– Shotgun metagenomics implicated Proteobacteria and microbial functions that convert AA into tryptophan as negatively associated with attention; bariatric surgery partially reversed these features.
