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This large-scale UK Biobank analysis identifies high lipoprotein(a) (Lp(a)) concentrations as a significant risk marker for incident extracoronary atherosclerotic vascular diseases, including peripheral artery disease (PAD) and carotid artery stenosis, and their subsequent complications. Elevated Lp(a) associates with increased risk of major adverse limb events and suggests potential for guiding risk stratification beyond traditional lipid measurements.
