Highlights
- Adjunctive L-carnitine and selenium (LCT/Se) therapy significantly accelerates the time to TSH-receptor antibody (TRAb) negativity (HR = 2.35).
- Patients receiving the combined supplement required a significantly lower cumulative dose of methimazole (MMI) compared to those on monotherapy.
- The intervention group demonstrated a markedly higher rate of spontaneous remission (OR = 11.22) over a 24-month period.
- LCT/Se supplementation specifically mitigated symptoms of tremor, irritability, and exertional dyspnea, independent of thyroid hormone levels.
Background and Clinical Challenges in Graves’ Disease
