Immune checkpoint inhibitor (ICI) rechallenge after immune-related adverse event (irAE)-induced treatment interruption in classical Hodgkin lymphoma (cHL) is feasible and generally safe.
Progression-free survival (PFS) and duration of response (DOR) were not significantly different between patients who underwent ICI rechallenge and those who did not within the same treatment line.
Recurrent irAEs occurred in 20% of rechallenged patients, with recurrence of the same irAE in only 7%, indicating manageable safety signals.
In patients rechallenged at subsequent therapy lines, median PFS varied notably depending on prior response, highlighting the influence of disease status on outcomes.
