Highlights
– A prespecified pooled individual‑level analysis (FLUNITY‑HD) of 466,320 participants randomized to high‑dose or standard‑dose influenza vaccine showed superior protection for high‑dose vaccine against hospitalisation for influenza or pneumonia (rVE 8.8%, 95% CI 1.7–15.5).
– High‑dose vaccine produced larger relative reductions for laboratory‑confirmed influenza hospitalisation (rVE 31.9%, 19.7–42.2) and ICD‑10–coded influenza hospitalisation (rVE 39.6%, 26.4–50.5).
