Highlights
- EASE-CD is a newly developed and externally validated index for quantifying endoscopic ulcer activity in Crohn’s disease.
- Demonstrates substantial inter-rater reliability (ICC=0.798) and strong responsiveness to treatment (WinP=0.769).
- Improves upon older indices by offering clearer definitions, better reliability, and validated thresholds for clinically meaningful change.
- Provides a continuous score (0–100) with ulcer-free remission defined as zero.
Clinical Background and Disease Burden
