Early pregnancy (10-14 weeks) oral glucose tolerance test (OGTT) and continuous glucose monitoring (CGM) data improve prediction of gestational diabetes mellitus (GDM) beyond clinical factors alone.
Adding OGTT to clinical risk factors increased the positive predictive value for GDM from 12.2% to 26.5% while maintaining a high negative predictive value (≥96%).
Neither early pregnancy OGTT nor CGM added predictive value for large-for-gestational-age (LGA) birth weights over clinical factors.
These findings support potential benefits of early glycemic assessment to identify women at risk for GDM and guide earlier interventions.
