Uterine artery Doppler at 35-36 weeks reflects primarily placental angiogenic imbalance associated with preeclampsia.
Placental growth factor (PlGF) mediates approximately 40% of the association, with soluble fms-like tyrosine kinase-1 (sFlt-1) mediating about 9%.
Ophthalmic artery hemodynamic changes account for 15% mediation, while arterial stiffness (cfPWV) shows no significant impact.
After adjusting for angiogenic and vascular variables, the uterine artery Doppler pulsatility index loses independent predictive value for preeclampsia.
