Highlight
- Cockroach subcutaneous immunotherapy (SCIT) modulates immunodominant T-cell responses in children with asthma.
- Down-modulation of Th2-polarized responses occurred regardless of the abundance of specific allergens in the SCIT extract.
- Immunotherapy efficacy did not depend on extract content, suggesting broader applicability of current formulations.
- Findings may inform strategies for allergen standardization and optimization in pediatric asthma management.
Background
