Treatment Retention in Opioid Use Disorder During Pregnancy: Buprenorphine vs Methadone Discontinuation Patterns

Buprenorphine initiators during early pregnancy show significantly higher treatment discontinuation rates than those initiating methadone.
Treatment discontinuation remains high for both buprenorphine and methadone through one year postpartum.
The discontinuation risk is notably higher with buprenorphine/naloxone combination compared to buprenorphine alone.
Findings underscore the urgent need to identify barriers to treatment retention among pregnant patients with opioid use disorder.