Transthyretin Cardiac Amyloidosis in Older Black and Hispanic Patients with Heart Failure: Prevalence, Genetics, and Clinical Implications

ATTR-CA was identified in 6.66% of older Black and Caribbean Hispanic individuals with heart failure, with a higher prevalence in Black participants (7.82%) than Hispanic participants (2.15%).
Approximately 44% of ATTR-CA cases were attributable to the hereditary V142I TTR gene variant, prevalent in 5.6% of the cohort.
Prevalence of ATTR-CA is notably higher in Black men over 75 years, reaching 17.17%, underscoring the need for targeted screening.
Over half of ATTR-CA cases showed wild-type TTR genotype, affirming the relevance of both hereditary and non-hereditary forms in heart failure etiology.

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