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– In a population-based cohort of 178,280 women from UK Biobank, higher baseline endogenous testosterone was associated with lower prevalence and delayed onset of knee osteoarthritis (KOA).
– Each 1 standard deviation (SD) increase in testosterone was associated with a 9% lower odds of prevalent KOA (OR 0.91; 95% CI 0.87–0.96) and a 4% longer time to incident KOA (time ratio 1.04; 95% CI 1.01–1.06) over a median 13.6-year follow-up.
