Highlight
- Macrophage CD36 mediates uptake of hepatic stellate cell-derived lipids, triggering lipid peroxidation and ferroptosis, impairing adaptive immunity.
- Myeloid-specific CD36 deficiency enhances macrophage antigen presentation via cGAS-STING pathway activation and promotes CD8+ T cell activation in liver fibrosis.
- Single-cell RNA sequencing reveals upregulation of MHC-I genes in CD36-deficient macrophages within fibrotic liver microenvironment.
- Clinical correlations demonstrate elevated CD36 expression in cirrhotic patients, supporting translational relevance of targeting CD36 in hepatic fibrosis.
Study Background and Disease Burden
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